DETAIL : MICROBIOLOGY& IMMUNOLOGY Initiated, for the first time in India, studies on molecular epidemiology and genetics of multi-drug resistant (MDR) M. tuberculosis (M.tb). These studies highlighted: a) the emergence of rifampicin as a surrogate marker for MDR – an observation now universally accepted for rapid diagnosis of MDR; and b) the presence of critical […]
DETAIL : GENETICS & CELL BIOLOGY Generated novel DNA probes for fingerprinting; Conducted the first study of its kind on genetic polymorphism within Indian human population; Demonstrated for the first time, genetic basis of extinction of endangered species and co-developed molecular markers for identification; Co-identified novel genetic loci, termed as meng, associated exclusively with human […]
DETAIL : GENE EXPRESSION He established baculovirus insect cell expression system (BEVS) for the first time in India and used this to express foreign genes (>50) and also to ask fundamental questions concerning gene expression in BEVS. Demonstrated correct processing and intracellular deposition of expressed proteins; Discovered the phenomenon of secretory load; Developed BEVS as […]